We all are aware of the fact that performance of an organization is definitely an important factor for proper output of an organization. So, performance based measurement of organizational performance is commonly used tool in the recent years. In this research paper, I would be presenting on six selected general but crucial operational performance-based indicators, i.e. effectiveness, efficiency, productivity, profitability, returns on investment, and benefit-cost ratio and their applications as well. With each measurement, their goals and potential impacts have also been explored. Also, errors, risks, limitations to measurements have been studied and a final check for validity, applicability, accountability, and usability of these measurements are also discussed. This research paper will also prove to be a simple, yet, practical guide to measurement of organizational performance as well as human performance technology practitioners’ accountability. Thus, this research paper would prove to be an asset that will add to continuous improvement of not only the organization but the human practitioners too.