The study examines the impact of employee grit and organizational culture on organizational change management within the Ministry of Food and Agriculture, Ghana. A positivist approach was employed, utilizing quantitative data collection through questionnaires. The population comprises employees of the Ministry of Food and Agriculture. Simple random sampling techniques were utilized to select participants. With a sample size of 300, a cross-sectional survey approach was adopted. IBM SPSS version 28 was used for data analysis. The study found that employee grit negatively affects organizational change (-0.251), contradicting research that links grit to adaptability. Organizational culture positively influences change (0.409), but strong cultures can also create resistance. Recommendations of the study and directions for future studies have been discussed.