Electronic commerce (E-commerce) is a form of transaction completed over a computer mediated network that involves the transfer of ownership or rights to use goods or services. It is about technology- enabled transactions. This paper presents Consumer Awareness and Satisfaction with E-commerce in Mumbai Region. The data was collected from e-commerce customers who purchase various kinds of product through e-commerce websites. Data was collected from total 1250 e-commerce customers in different areas of Mumbai Region. Data was analyzed using Chi-Square. Data analysis revealed that majority of customers are aware of e-commerce but afraid of answering too many personal questions while purchasing a product online; customers prefer e-commerce websites those do not seek for much personal information. It was observed that to find information customers use e-commerce but they select e-commerce site which is easy to use.