IR 4.0 is taking place in many developed countries and provides opportunities for developing countries, helping to shorten the industrialization process by taking short cuts, leaps and bounds to higher technology. It gives mankind the opportunity to change the faces of economies, but there are hidden risks. Over the past few days, the concept of IR 4.0 has been mentioned a lot on media and social networks. Along with that is the promise of changing the life of businesses in Vietnam if this wave is welcomed. Economic uncertainties arising from the IR 4.0 will lead to instability in life. Its consequences will be the political fragility and instability. If governments do not fully understand and prepare for the IR 4.0, the risk of global instability is forthcoming. So, managing change in technology enterprises in the era of IR 4.0 should be important topic ò research in this article.